The History of Medical Care in Holyoke is a lengthy topic.
| name | reason | location | information | start | end |
| Providence Hospital | general | information | 1873 | ||
| Holyoke Hospital | general | Beech Street | information | 1893 | |
| Carpenter Hospital (Isolation Hospital) | tuberculosis | Cherry Street | information | 1918 | 1937 |
| Clarke Surgical Hospital | Smith’s Ferry | information | 1920 | ||
| Infectious Hospital | infections | Jarvis Avenue | information | 1918 | |
| Municipal Home Hospital | information | ||||
| Pest House | infections | information | |||
| Holyoke Contagious Disease Hospital (Holyoke Sanatorium) | infections | Cherry Street | information | 1912 | 1937 |
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