The Spanish American War was fought from 1898 to 1899. Eight men from Holyoke lost their lives in the battles.
| name | enlistment date | rank and notes | death date and age | death location | burial |
| Joseph Bonneville | 3 May 1898 | private | 9 Aug 1898 | Santiago de Cuba, Cuba | FINDAGRAVE |
| James Brady | 27 Sept 1898 at 19 | ||||
| George Collier | 3 May 1898 | sergeant | 23 Sep 1898 at 26 | Holyoke, MA | FINDAGRAVE |
| Anatole Dugas | 3 May 1898 | private | 2 Jul 1898 at 28 | Santiago de Cuba, Cuba | FINDAGRAVE |
| William Dugas | 14 July 1899 | captured and murdered by insurgents | 26 Sept 1900 | Calmog Philippines | FINDAGRAVE |
| Patrick Fallon | malaria and pneumonia | 5 January 1900 | FINDAGRAVE | ||
| Frank G Mattice | sergeant | 15 September 1898 | Holyoke | FINDAGRAVE | |
| Edgar R Train | quartermaster sergeant / malaria | 27 August 1898 | Montaul Point New York | FINDAGRAVE |