The schools in Holyoke started out with many one room schoolhouses. Then in 1850 a larger school was needed in the urban core.
| school | location | starts | ends | becomes | |
| Chestnut Street School | Chestnut | 1850 | North Chestnut Street School and then rebuilt as William Whiting School 1910 and then Holyoke Catholic High School – note was 1852 to 1862 Holyoke High School | ||
| Lyman Street School | 1862 | 1901 | part of Holy Rosary campus | ||
| Elm Street School | 1862 | 1898 | Holyoke High School | ||
| Carlton Street School | Carlton | 1865 | |||
| Ewingville School | 1865 | 1921 | |||
| West Holyoke School | 1867 | ||||
| Appleton Street School | 1867 | Lawrence School and then replaced by War Memorial | |||
| Park Street School | 1868 | Convent of St Anne nuns | |||
| Sargeant Street School | Sargeant | 1869 | |||
| East Dwight Street School | 1880 | Immaculate Conception School | |||
| Nonotuck Street School | 1883 | ||||
| South Chestnut Street School | 1885 | ||||
| Hamilton Street School | 1887 | Precious Blood High School | |||
| Elmwood Street School | 1894 | ||||
| Bridge Street School | 1894 | 1907 | |||
| West Street School | 1896 | Kelly School | |||
| Holyoke High School | Beech Street | 1898 | 1964 | ||