The nuns of Holyoke are varied since there are so many ethnic groups within the city. Below is a rundown of the orders and when and where they served.
| order | location | years in Holyoke | local burial locations | motherhouse | external link to their history |
| Notre Dame | Notre Dame School | 1869 -1910 | Saint Jerome Cemetery in Holyoke | Waltham Massachusetts | HISTORY |
| Sisters of Saint Joseph | St Jerome – Rosary (1920 on) – Sacred Heart | 1886 – today | St Michael’s Cemetery of Springfield and Mont Marie Cemetery of Holyoke | Springfield | HISTORY |
| Franciscan Sisters of Saint Joseph | Mater Dolorosa | 1906 – 1994 | HISTORY | ||
| Sisters of Sainte Anne | Precious Blood | 1888 – 1971 | Nicolet of Quebec Canada | HISTORY | |
| Sisters of the Presentation of Mary | Immaculate Conception – Perpetual Help | 1891 – 1979 | HISTORY | ||
| Sisters of Providence | LINK | November 1873 – today | Calvary Cemetery of the Sisters of Providence in Holyoke | Holyoke | HISTORY |